Sushmita Sen as Rupali Walia – Prem's mistress Lovely's friend Deepak's ex girlfriend.

Their plan succeeds when they invite Rupali's ex boyfriend Deepak to Khurana house, and Rupali unites with him, leaving Prem. He works as an doctor, and is Pooja's partner in getting Prem back to her and breaking his relationship with Rupali. Lakhan Singh Khurana – Prem's friend Lovely's husband Billu's father. After Prem leaves the house to move in with his mistress Rupali, Pooja takes Lakhan's help and does several attempts that are successful in Prem breaking up with Rupali.

Karisma Kapoor as Pooja Mehra (née Makhija) – Kamal and Pari's daughter Prem's wife Lakshmi's daughter-in-law Rinku and Pinky's mother.

With Lakhan's help, Pooja succeeds in breaking Prem's relationship with Rupali and in the end, he returns and apologizes to Pooja. He is a wealthy businessman and reckless car driver who begins an extramarital affair with Rupali, and leaves his own house to move in with her after Pooja learns the truth.

Salman Khan as Prem Mehra – Lakshmi's son Lakhan's friend Pooja's husband Kamal and Pari's son-in-law Rinku and Pinky's father.

He says to Lovely that she is his 'Biwi no. She leaves, but Lakhan chases after and they make up as she realises the truth. While hugging her, his wife Lovely sees them and misunderstands. Lakhan befriends her, calling her his sister.

Rupali gets back with her ex-boyfriend Deepak. Prem realizes she only came to him since he gave her material things, while Pooja stuck with him via thick and thin. Ultimately the relationship between Prem and Rupali breaks down. They intentionally trouble Rupali and tell Prem that she keeps them hungry and wants to poison and kill them. Pooja sends her mother-in-law Lakshmi and children to live with Prem and Rupali. With the help of Prem's friend Lakhan Khurana, she has a make-over turning modern and taking on modeling assignments. He chooses and moves in with Rupali, leaving his family behind with Pooja.

Pooja learns about them and asks Prem to choose between Rupali or his family. Rupali is much preferable to Prem due to her modern lifestyle and fashionable choices as compared to Pooja. They are attracted to each other, ultimately fall in love and begin a romantic relationship. Rupali Walia arrives at Prem's office to give interview for role of a model. Prem Mehra is married to the loving yet traditional Pooja Makhija, and they have 2 children.

Biwi no 1 english subtitles